• Mahesh Fuldeore, Hongbo Yang, Ella Xiaoyan Du, Ahmed M Soliman, Eric Q Wu, and Craig Winkel.
• AbbVie, Inc., North Chicago, Illinois. Electronic address: Mahesh.fuldeore@abbvie.com.
• Fertil. Steril. 2015 Jan 1; 103 (1): 163-71.

ObjectiveTo assess healthcare resource utilization and costs during the 5 years before and 5 years after diagnosis among women with endometriosis, in comparison with women without endometriosis.DesignLongitudinal, retrospective, case-control study.SettingNone.Patient(S)A total of 37,570 matched pairs of women with and without (controls) endometriosis were identified from the Truven Health MarketScan claims database (2000-2010).Intervention(S)None.Main Outcome Measure(S)Annual healthcare resource utilization and costs (in 2010 US dollars) were evaluated for the 5 years before and 5 years after diagnosis.Result(S)Mean patient age at index (first diagnosis) date was 36.4 years for endometriosis patients and controls. Endometriosis patients had a higher utilization of outpatient and emergency room services during each pre- and postindex year, and a higher utilization of inpatient services during the last preindex year and all 5 postindex years. Total costs were highest in the first postindex year for endometriosis patients, reaching $13,199, compared with $3,747 for controls. Annual costs were significantly higher for patients than controls during each pre- and postindex year; overall, the cost difference was $26,305 over 10 years: $7,028 in the 5 years before diagnosis and $19,277 in the 5 years after diagnosis.Conclusion(S)Endometriosis poses a significantly high economic burden, both before and after diagnosis. The highest resource utilization and costs experienced by endometriosis patients occur in the first year after diagnosis.Copyright © 2015 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

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