• Prehosp Disaster Med · Jun 2017

    Impact of Early Vasopressor Administration on Neurological Outcomes after Prolonged Out-of-Hospital Cardiac Arrest.

    • Michael W Hubble and Clark Tyson.
    • 1Emergency Medical Care Program,School of Health Sciences,Western Carolina University,Cullowhee,North CarolinaUSA.
    • Prehosp Disaster Med. 2017 Jun 1; 32 (3): 297-304.

    AbstractIntroduction Vasopressors are associated with return of spontaneous circulation (ROSC), but no long-term benefit has been demonstrated in randomized trials. However, these trials did not control for the timing of vasopressor administration which may influence outcomes. Consequently, the objective of this study was to develop a model describing the likelihood of favorable neurological outcome (cerebral performance category [CPC] 1 or 2) as a function of the public safety answering point call receipt (PSAP)-to-pressor-interval (PPI) in prolonged out-of-hospital cardiac arrest. Hypothesis The likelihood of favorable neurological outcome declines with increasing PPI.

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