• J Headache Pain · Jul 2018

    Review

    Medication-overuse headache: a widely recognized entity amidst ongoing debate.

    • Nicolas Vandenbussche, Domenico Laterza, Marco Lisicki, Joseph Lloyd, Chiara Lupi, Hannes Tischler, Kati Toom, Fenne Vandervorst, Simone Quintana, Koen Paemeleire, and Zaza Katsarava.
    • Headache Group, Department of Basic and Clinical Neuroscience, King's College London, and NIHR-Wellcome Trust King's Clinical Research Facility, King's College Hospital, Denmark Hill, London, SE5 9PJ, UK. Nicolas.vandenbussche@kcl.ac.uk.
    • J Headache Pain. 2018 Jul 13; 19 (1): 5050.

    AbstractMedication overuse in primary headache disorders is a worldwide phenomenon and has a role in the chronification of headache disorders. The burden of disease on individuals and societies is significant due to high costs and comorbidities. In the Third Edition of the International Classification of Headache Disorders, medication-overuse headache is recognized as a separate secondary entity next to mostly primary headache disorders, although many clinicians see the disease as a sole complication of primary headache disorders. In this review, we explore the historical background of medication-overuse headache, its epidemiology, phenomenology, pathophysiology and treatment options. The review explores relevant unanswered questions and summarizes the current debates in medication-overuse headache.

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