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Ugeskrift for laeger · Mar 2015
Review[Inhibition of the protein PCSK9 is a promising target in the prevention of cardiovascular disease].
- Morten Krogh Christiansen and Henrik Kjærulf Jensen.
- Ugeskr. Laeg. 2015 Mar 9; 177 (11).
AbstractRecent research in genetics has revealed that PCSK9 - which codes for proprotein convertase subtilisin/kexin type 9 (PCSK9) - plays a major role in cholesterol regulatory pathways. Normal genetic variations in PCSK9 have a great impact on low-density lipoprotein cholesterol levels and hence the risk of cardio-vascular disease. This has led to huge efforts in inhibiting PCSK9. Recent clinical phase II trials with monoclonal antibodies against PCSK9 have shown great results for lowering low-density lipoprotein cholesterol levels making the inhibition of PCSK9 a promising target in the prevention of cardiovascular disease.
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