• Eduardo T Moro, Miller F Lambert, Ana Luiza Pereira, Thaís Artioli, Giuliana Graicer, Juliana Bevilacqua, and Joshua Bloomstone.
• Department of Surgery, School of Medical and Health Sciences, Pontifical Catholic University of São Paulo, PUC-SP, São Paulo, SP, Brazil.
• J Clin Anesth. 2019 Mar 1; 53: 64-69.

Study ObjectivesThe aim of the present study was to assess the quality of recovery from anesthesia in patients undergoing laparoscopic cholecystectomy (LC) under total intravenous anesthesia, who received either methadone or morphine for post-surgical analgesia by means of questionnaire Quality of Recovery-40 (QoR-40).DesignProspective Randomized Clinical Trial.SettingThe setting was at an operating room, postoperative recovery area and hospital ward.PatientsSeventy patients who underwent LC under remifentanil-based anesthesia were randomly assigned to receive methadone 0.1 mg kg-1 or morphine 0.1 mg kg-1.MeasurementsThe primary outcome was the quality of recovery, using the Quality of Recovery Questionnaire (QoR-40). Secondary outcomes included time to eye opening, the occurrence of nausea and vomiting, pain score, use of supplemental analgesics, and PACU length of stay.Main ResultsNo differences were observed in the total or individual QoR-40 dimension scores. During the PACU stay, the occurrence of PONV and pain scores were similar between groups. Opioid consumption (p < 0.02) and the level of sedation (p < 0.01) were higher in the morphine group. There were no differences in the amount of time required to achieve PACU discharge criteria. The frequency of nausea or emesis, the severity of pain, and tramadol consumption were comparable between both groups while on the ward.ConclusionsPain scores and the Quality of Recovery did not differ between patients who underwent LC under total intravenous anesthesia, who received either methadone or morphine for post-surgical analgesia.Copyright © 2018 Elsevier Inc. All rights reserved.

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