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- Erika L Brinson, Jane S Yu, Linda L Liu, and Michael P Bokoch.
- From the Department of Anesthesia and Perioperative Care, University of California, San Francisco, California.
- A A Pract. 2018 Aug 1; 11 (3): 82-84.
AbstractPatients with end-stage liver disease are often hyponatremic due to multiple physiological processes associated with hepatic failure. For severely hyponatremic patients undergoing liver transplantation, intraoperative management of serum sodium concentration ([Na]s) is challenging. [Na]s tends to increase during transplantation by the administration of fluids with higher sodium concentration than the patient's [Na]s. An overly rapid increase in [Na]s (>1 mEq·L·hour) is difficult to avoid and increases the risk of serious perioperative complications. We report the successful use of intravenous desmopressin to reverse an overly rapid rise in [Na]s during living donor liver transplantation.
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