• Anesthesia and analgesia · Jan 2020

    Clinical Trial

    Serum Concentrations of Lidocaine During Bariatric Surgery.

    • Jean-François Carabalona, Benjamin Delwarde, Antoine Duclos, Mary-Charlotte Le Goff, Mustapha Moulsma, Antony Citterio-Quentin, Yves Bouffard, and Thomas Rimmelé.
    • From the *Département d'Anesthésie-Réanimation, Groupement Hospitalier Édouard Herriot, Hospices Civils de Lyon, Lyon, France †Equipe d'Accueil 7426 "Pathophysiology of Injury-Induced Immunosuppression" Hospices Civils de Lyon - bioMérieux - Université Claude Bernard Lyon 1, Lyon, France ‡Pôle de Santé publique, Hospices Civils de Lyon, F-69003 Lyon, France §Health Services and Performance Research Laboratory, HEalth Services and PERformance Research Equipe d'Accueil 7425, Université Claude Bernard Lyon 1, F-69008 Lyon, France ‖Laboratoire de Biologie Médicale Multi Sites du Centre Hospitalo-Universitaire de Lyon, unité de Pharmacologie, Toxicologie et Eléments trace, Groupement Hospitalier Edouard Herriot, Hospices Civils de Lyon, Lyon, France ¶Laboratoire de Biologie Médicale Multi Sites du Centre Hospitalo-Universitaire de Lyon, unité de Pharmacologie, Toxicologie et Eléments trace, Groupement Hospitalier Lyon Sud, Hospices Civils de Lyon, Lyon, France.
    • Anesth. Analg. 2020 Jan 1; 130 (1): e5-e8.

    AbstractLidocaine has been shown to be clinically beneficial during bariatric surgery. However, information about lidocaine serum concentrations in this setting is scarce. This prospective clinical trial included 42 obese patients undergoing laparoscopic bariatric surgery. They received lidocaine based on adjusted body weight. Administration began with a 1.5 mg·kg bolus of intravenous lidocaine followed by a continuous infusion of 2 mg·kg·hour. After skin closure, administration was decreased to 1 mg·kg·hour until discharge from the recovery room. No serum concentrations of lidocaine were outside the usual accepted range (1.5-5 µg·mL).

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