• Rosa Mar Gómez Punter, Rosa M Girón Moreno, Emma Vázquez Espinosa, Joan B Soriano, M Teresa Pastor, Enrique Zamora, Claudia Valenzuela, Tamara Alonso, Elena García Castillo, and Julio Ancochea.
• Servicio de Neumología. Instituto de Investigación Sanitaria Princesa (IISP), Hospital Universitario La Princesa, Universidad Autónoma de Madrid, Madrid, Spain. rosamar_gp@hotmail.com.
• Respir Care. 2019 Jan 1; 64 (1): 48-54.

BackgroundNocturnal desaturation in cystic fibrosis (CF) may have prognostic implications because a significant and maintained nocturnal desaturation can contribute to the development and progression of pulmonary hypertension with cor pulmonale. Its relation with the desaturation in exercise has not been sufficiently studied. We aimed to determine whether desaturation during 6MWT can be an indicator of nocturnal desaturation in adult subjects with CF.Methods57 subjects were included: 50.9% male, 27.5 ± 7.7 y old, mean FEV1 = 2.37 ± 0.74 L, and %FEV1 67 ± 18.1%. Desaturation during 6MWT was defined as oxygen saturation (SpO2 ) ≤ 90% or a decline of > 4 points in SpO2 from baseline, and nocturnal desaturation as a desaturation index > 4 or > 5% of sleep time with SpO2 ≤ 90%.ResultsDesaturation observed during 6MWT in adult subjects with CF did not correlate with nocturnal desaturation (P = .27). Subjects with %FEV1 ≤ 55% and diffusion capacity of carbon monoxide (DLCO) ≤ 50 mmol/min/mm Hg were at higher risk of 6MWT desaturation. Nocturnal desaturation was more frequent in males, with PaO2 ≤ 71 mm Hg in blood gas analysis.ConclusionsDesaturation observed in 6MWT cannot predict desaturation at night in adults with CF. Other parameters were identified as predictors of desaturation.Copyright © 2019 by Daedalus Enterprises.

29 keywords...

hide…