• Melih Akın, Başak Erginel, Nihat Sever, Kerem Özel, Banu Bayraktar, Abdullah Yıldız, Çetin Ali Karadağ, Meltem Tokel, and Ali İhsan Dokucu.
• Department of Pediatric Surgery, Şişli Hamidiye Etfal Training and Research Hospital, İstanbul-Turkey. basakerginel@hotmail.com.
• Ulus Travma Acil Cer. 2018 Mar 1; 24 (2): 110-115.

BackgroundSoluble urokinase plasminogen activator receptor (suPAR) is a new biomarker of inflammation level. The aim of the study was to evaluate whether suPAR levels could be useful to detect acute appendicitis and to differentiate uncomplicated appendicitis (UA) from complicated appendicitis (CA).MethodsWe prospectively studied 105 patients consisting of 40 UA cases, 40 CA cases, and 25 control patients. Blood samples were collected to measure suPAR level, C-reactive protein level, leukocyte counts, neutrophil counts, and neutrophil percentages preoperatively.ResultsMedian values of suPAR level, C-reactive protein level, leukocyte counts, neutrophil counts, and neutrophil percentages in UA and CA were significantly higher than control patients. suPAR levels of the UA and CA groups showed a statistically significant difference (p=0.016).ConclusionThe current study demonstrated that serum suPAR concentrations can be helpful in differentiating CA from UA and in diagnosing acute appendicitis.

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