• Charlotte Guhl, Frank Birklein, and Silke Hirsch.
• Klinik und Poliklinik für Neurologie, Unimedizin Mainz, Mainz, Germany.
• Eur J Pain. 2019 Apr 1; 23 (4): 835-842.

BackgroundHypersensitivity and altered sweating are often present in neuropathy patients. Nerve lesions are known to produce sudomotor dysfunctions but also patients suffering from complex regional pain syndrome, CRPS1-a condition without a nerve lesion-present with sweating disorders.MethodsUsing proton nuclear magnetic resonance of sweat water, we quantified sweat output of mice suffering from a nerve lesion or a bone fracture without nerve lesion and correlated their sweating with behavioural paw hypersensitivity accessed in von Frey testings, water applications and weight-bearing measured with an incapacitance metre.ResultsLesioned animals sweat less and are hypersensitive compared to healthy controls, as expected. Fractured animals on the injured side sweat less acutely after the injury but more in the chronic phase. They are hypersensitive acutely as well as chronically after the fracture. These findings resemble human bone trauma patients in the acute phase and CRPS patients in the chronic phase.ConclusionsSweating disorders are present both in neuropathic animals and in those with a bone fracture without nerve lesions, and autonomic dysfunctions might be considered as an important component in the aetiology of neuropathies.SignificanceSweat output changes in mice after bone trauma, potentially indicative of posttraumatic processes leading to CRPS in humans.© 2018 European Pain Federation - EFIC®.

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