• Jiaying Luo, Sichang Xiao, Zhihui Qiu, Ning Song, and Yuanming Luo.
• Sleep Center, State Key Laboratory of Respiratory Disease, Guangzhou Medical College, Guangzhou, China.
• Respirology. 2013 Apr 1; 18 (3): 528-33.

Background And ObjectiveWhether the therapeutic nasal continuous positive airway pressure (CPAP) derived from manual titration is the same as derived from automatic titration is controversial. The purpose of this study was to compare the therapeutic pressure derived from manual titration with automatic titration.MethodsFifty-one patients with obstructive sleep apnoea (OSA) (mean apnoea/hypopnoea index (AHI) = 50.6 ± 18.6 events/h) who were newly diagnosed after an overnight full polysomnography and who were willing to accept CPAP as a long-term treatment were recruited for the study. Manual titration during full polysomnography monitoring and unattended automatic titration with an automatic CPAP device (REMstar Auto) were performed. A separate cohort study of one hundred patients with OSA (AHI = 54.3 ± 18.9 events/h) was also performed by observing the efficacy of CPAP derived from manual titration.ResultsThe treatment pressure derived from automatic titration (9.8 ± 2.2 cmH(2)O) was significantly higher than that derived from manual titration (7.3 ± 1.5 cmH(2)O; P < 0.001) in 51 patients. The cohort study of 100 patients showed that AHI was satisfactorily decreased after CPAP treatment using a pressure derived from manual titration (54.3 ± 18.9 events/h before treatment and 3.3 ± 1.7 events/h after treatment; P < 0.001).ConclusionsThe results suggest that automatic titration pressure derived from REMstar Auto is usually higher than the pressure derived from manual titration.© 2013 The Authors. Respirology © 2013 Asian Pacific Society of Respirology.

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