Test Characteristics of Cerebrospinal Fluid Gram Stain to

Pediatric emergency care · May 2021

Test Characteristics of Cerebrospinal Fluid Gram Stain to Identify Bacterial Meningitis in Infants Younger Than 60 Days.

In our cohort of 20,947 infants aged 60 days or younger, cerebrospinal fluid Gram stain had a sensitivity of 34.3% (95% confidence interval, 28.1%-41.1%) and a positive predictive value of 61.4% (95% confidence interval, 52.2%-69.8%) for positive cerebrospinal fluid culture, suggesting that Gram stain alone may lead to both underdiagnosis and overdiagnosis of bacterial meningitis.

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- Fran Balamuth, Andrea T Cruz, Stephen B Freedman, Paul T Ishimine, Aris Garro, Sarah Curtis, Kendra L Grether-Jones, Aaron S Miller, Neil G Uspal, Suzanne M Schmidt, Samir S Shah, Lise E Nigrovic, and Pediatric Emergency Medicine Collaborative Research Committee (PEMCRC) HSV Study Group.
- From the Division of Emergency Medicine, Children's Hospital of Philadelphia, Philadelphia, PA.
- Pediatr Emerg Care. 2021 May 1; 37 (5): e227e229e227-e229.
AbstractIn our cohort of 20,947 infants aged 60 days or younger, cerebrospinal fluid Gram stain had a sensitivity of 34.3% (95% confidence interval, 28.1%-41.1%) and a positive predictive value of 61.4% (95% confidence interval, 52.2%-69.8%) for positive cerebrospinal fluid culture, suggesting that Gram stain alone may lead to both underdiagnosis and overdiagnosis of bacterial meningitis.Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.

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Test Characteristics of Cerebrospinal Fluid Gram Stain to Identify Bacterial Meningitis in Infants Younger Than 60 Days.

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