• Nataly Simões Bandiera Thimóteo, Tatiana Mayumi Veiga Iryioda, Daniela Frizon Alfieri, Brunna Emanuella França Rego, Bruna Miglioranza Scavuzzi, Elis Fatel, Lozovoy Marcell Alysson Batisti MAB Research Laboratory in Applied Immunology, University of Londrina, Londrina, Paraná, Brazil; Department of Pathology, Clinical Analysi, Simão Andréa Name Colado ANC Research Laboratory in Applied Immunology, University of Londrina, Londrina, Paraná, Brazil; Department of Pathology, Clinical Analysis and T, and Isaias Dichi.
• Research Laboratory in Applied Immunology, University of Londrina, Londrina, Paraná, Brazil.
• Nutrition. 2019 Apr 1; 60: 112-117.

ObjectivesStudies have shown that cranberry (Vaccinium macrocarpon) has antiinflammatory and antioxidant effects; however, to our knowledge, the effects of cranberry juice consumption have not been studied in patients with rheumatoid arthritis (RA). The aim of this study was to verify the effect of cranberry juice consumption on several inflammatory biomarkers and on the disease activity of patients with RA.MethodsA prospective study was conducted with 41 women diagnosed with RA. The disease activity measured by Disease Activity Score 28 (DAS28) and anticyclic citrullinated peptide (anti-CCP) antibodies, and several inflammatory and biochemical biomarkers were analyzed. The control group (n = 18) maintained their usual diet. The cranberry group (n = 23) consumed 500 mL/d of low-calorie cranberry juice.ResultsRegarding the baseline values, the cranberry group presented a decrease in the values of DAS28 (P = 0.048) and anti-CCP (P = 0.034) after 90 d of treatment, whereas changes in inflammatory biomarkers were not found.ConclusionThe present study indicated that cranberry juice decreases disease activity and therefore has beneficial effects for RA patients, although larger and long-term studies are needed to definitively probe this effect and to clarify the mechanisms involved.Copyright © 2019. Published by Elsevier Inc.

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