• Alfredo B Cuellar-Barboza, Mark A Frye, Karen Grothe, Miguel L Prieto, Terry D Schneekloth, Larissa L Loukianova, Daniel K Hall-Flavin, Matthew M Clark, Victor M Karpyak, Joseph D Miller, and Osama A Abulseoud.
• Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, United States; Department of Psychiatry, Universidad Autonoma de Nuevo Leon, Monterrey, Mexico.
• J Psychosom Res. 2015 Mar 1; 78 (3): 199-204.

ObjectiveThe aim of this study is to describe the clinical phenotype of alcohol use disorder (AUD) treatment-seeking patients with Roux-en-Y Gastric Bypass Surgery (RYGB) history; and to compare it to AUD obese non-RYGB controls.MethodsRetrospective study of electronic medical records for all patients 30-60years treated at the Mayo Clinic Addiction Treatment Program, between June, 2004 and July, 2012. Comparisons were performed with consumption patterns pre-RYGB and at time of treatment; excluding patients with AUD treatments pre-RYGB.ResultsForty-one out of 823 patients had a RYGB history (4.9%); 122 controls were selected. Compared to controls, the RYGB group had significantly more females [n=29 (70.7%) vs. n=35 (28.7%) p<0.0001]; and met AUD criteria at a significantly earlier age (19.1±0.4 vs. 25.0±1years old, p=0.002). On average, RYGB patients reported resuming alcohol consumption 1.4±0.2years post-surgery, meeting criteria for AUD at 3.1±0.5years and seeking treatment at 5.4±0.3years postoperatively. Pre-surgical drinks per day were significantly fewer compared to post-surgical consumption [2.5±0.4 vs. 8.1±1.3, p=0.009]. Prior to admission, RYGB patients reported fewer drinking days per week vs. controls (4.7±0.3 vs. 5.5±1.8days, p=0.02). Neither RYGB, gender, age nor BMI was associated with differential drinking patterns.ConclusionThe results of this study suggest that some patients develop progressive AUD several years following RYGB. This observation has important clinical implications, calling for AUD-preventive measures following RYGB. Further large-scale longitudinal studies are needed to clarify the association between RYGB and AUD onset.Copyright © 2014 Elsevier Inc. All rights reserved.

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