• Resuscitation · Jan 2019

    Postmortem histopathology of electroencephalography and evoked potentials in postanoxic coma.

    • van Putten Michel J A M MJAM Clinical Neurophysiology, Medisch Spectrum Twente, Enschede, The Netherlands; Clinical Neur... more ophysiology, University of Twente, PO Box 217, 750, Casper Jansen, Marleen C Tjepkema-Cloostermans, Beernink Tim M J TMJ Clinical Neurophysiology, Medisch Spectrum Twente, Enschede, The Netherlands., Rob Koot, Frank Bosch, Albertus Beishuizen, and Jeannette Hofmeijer. less
    • Clinical Neurophysiology, Medisch Spectrum Twente, Enschede, The Netherlands; Clinical Neurophysiology, University of Twente, PO Box 217, 7500 KA Enschede, The Netherlands. Electronic address: m.j.a.m.vanp... more utten@utwente.nl. less
    • Resuscitation. 2019 Jan 1; 134: 26-32.

    AbstractEarly EEG patterns and SSEP responses are associated with neurological recovery of comatose patients with postanoxic encephalopathy after cardiac arrest. However, the nature and distribution of brain damage underlying the characteristic EEG and SSEP patterns are unknown. We relate EEG and SSEP findings with results from histological analyses of the brains of eleven non-survivors. With restoration towards continuous rhythms within 24 h after cardiac arrest, no signs of structural neuronal damage were observed. Absent SSEP responses were always accompanied by thalamic damage. Pathological burst suppression patterns were associated with a variable degree of neuronal damage to cortex, cerebellum and hippocampus. In patients with additional thalamic involvement, burst-suppression with identical bursts was observed, a characteristic EEG pattern presumably reflecting residual activity from a relatively isolated and severely compromised cortex.Copyright © 2018 Elsevier B.V. All rights reserved.

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