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Trans. R. Soc. Trop. Med. Hyg. · Jan 2005
Case ReportsTreatment of acute vivax malaria with tafenoquine.
- Peter Nasveld and Scott Kitchener.
- Clinical Field Section, Australian Army Malaria Institute, Gallipoli Barracks, Enoggera, Queensland 4051, Australia. peter.nasveld@defence.gov.au
- Trans. R. Soc. Trop. Med. Hyg. 2005 Jan 1; 99 (1): 2-5.
AbstractTafenoquine is an 8-aminoquiniline related to primaquine with pre-clinical activity against a range of malaria species. We treated two acute cases of vivax malaria with tafenoquine (800 mg over three days) alone, instead of conventional chloroquine (1500 mg over three days) and primaquine (420 mg over 14 days). In addition to the convenience of this regimen, the rapid parasite clearances observed, coupled with a good clinical response and lack of recrudescence or relapse, indicate that further investigation of tafenoquine in the treatment of vivax malaria is warranted.
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