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- Irina Turchin, Linda Moreau, Erin Warshaw, and Denis Sasseville.
- McGill University Health Centre, Royal Victoria Hospital, Montreal, PQ, Canada.
- Dermatitis. 2006 Dec 1; 17 (4): 192-5.
BackgroundParabens are alkyl ester derivatives of para-hydroxybenzoic acid and are the most commonly used preservatives in the cosmetic industry. Cross-reactions with para-amino compounds, namely, benzocaine and para-phenylenediamine (PPD), have been reported but are thought to be extremely rare.ObjectiveTo evaluate the rate of cross-reactivity between parabens, PPD, and benzocaine in a population of patients patch-tested in a hospital-based contact dermatitis clinic.MethodsA retrospective analysis of 4,368 patients consecutively patch-tested between July 1989 and June 2005.ResultsOur study demonstrated that the rate of cross-reactions to parabens in PPD- and benzocaine-positive patients combined is 2%.ConclusionThis cross-reaction rate is significant in the tested population but still falls within the previously reported rates of sensitivity to parabens in the general population (0 to 3.5%).
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