• Ruchi Verma, Anil Agarwal, Prabhat Kumar Singh, Devendra Gupta, and Rafat Shamim.
• Department of Anesthesiology, T S Mishra Medical College and Hospital, Amausi, Lucknow, Uttar Pradesh, India.
• Anesth Essays Res. 2016 Sep 1; 10 (3): 613-617.

ContextCatheter-related bladder discomfort (CRBD) is the most distressing symptom in patients due to intraoperative urinary catheterization. Amikacin significantly inhibits detrusor contraction evoked by prejunctional stimulation.AimsThe aim of this study is to evaluate the efficacy of amikacin in prevention of CRBD in patients undergoing percutaneous nephrolithotomy.Settings And DesignStudy areas were operation theater and postanesthesia care unit of the Department of Anesthesiology, SGPGIMS, Lucknow.Subjects And MethodsOne hundred adult patients of either sex were randomly assigned into two groups of fifty each. Patients in control group received normal saline whereas patients in amikacin group received amikacin 10 mg/kg just before induction. Grading of CRBD was done as none, mild, moderate, and severe by a blinded observer at 0, 1, 6, 12, and 24 h after surgery.Statistical Analysis UsedData were analyzed using Student's t-test and Chi-square test among groups. Incidence of CRBD was compared with Chi-square test whereas severity was analyzed by the test of proportions (Z-test). Visual analog score was compared using Mann-Whitney U-test for surgical site pain.ResultsIncidence of CRBD in control group was 66% as compared to 44% observed in amikacin group (P < 0.05). During intergroup comparison at different time points, incidence of CRBD was reduced at 1 and 6 h in the amikacin group (P < 0.05). Significant reduction in the severity of CRBD (moderate) was also observed at 1 h in the amikacin group (P < 0.05). At rest of the time points, there was no significant difference.ConclusionsAmikacin can significantly reduce the incidence and severity of CRBD in the first few hours after surgery.

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