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Pediatric blood & cancer · Jul 2015
ReviewCD19: A multifunctional immunological target molecule and its implications for Blineage acute lymphoblastic leukemia.
- Judith Weiland, Alex Elder, Victoria Forster, Olaf Heidenreich, Steffen Koschmieder, and Josef Vormoor.
- Northern Institute for Cancer Research, Newcastle University, Newcastle-upon-Tyne, UK.
- Pediatr Blood Cancer. 2015 Jul 1; 62 (7): 1144-8.
AbstractOver the last 20-30 years CD19 has gained attention as a potential target in the therapy of B-cell malignancies. In particular, targeting CD19 with the bispecific T-cell engager (BiTE) antibody Blinatumomab and T-cells modified by chimeric antigen receptors (CAR) has shown promising efficacy in early phase clinical trials for adults and children with precursor B-cell ALL (BCP-ALL). This review will discuss the rationale behind targeting CD19 in BCP-ALL and its potential importance in BCP-ALL signaling pathways.© 2015 Wiley Periodicals, Inc.
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