Recent cocaine use was not associated with intraoperative hemodynamic instability.

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• Tiffany S Moon, Michael X Gonzales, Joshua J Sun, Agnes Kim, Pamela E Fox, Abu T Minhajuddin, Taylor J Pak, and Babatunde Ogunnaike.
• University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9068, USA. Electronic address: Tiffany.Moon@UTSouthwestern.edu.
• J Clin Anesth. 2019 Aug 1; 55: 146-150.

Study ObjectiveTo evaluate the intraoperative hemodynamics and medication requirements of cocaine-positive patients compared to matched cocaine-negative controls.DesignRetrospective cohort study.SettingPublic county hospital.Patients821 patients undergoing general anesthesia.MeasurementsIncidence of hemodynamic events, defined by a mean arterial pressure of <65 mmHg or >105 mmHg or a heart rate of <50 beats per minute or >100 beats per minute.Main ResultsCocaine-positive patients did not experience a higher incidence of hemodynamic events when compared with matched cocaine-negative patients. Cocaine-positive patients were not more likely to be administered vasopressors intraoperatively but did receive more anti-hypertensive agents. The minimum alveolar concentration of anesthetics used was similar between the two groups. Anesthesia duration, length of stay, and in-hospital mortality did not significantly differ between the two cohorts.ConclusionsCocaine-positive patients did not demonstrate more intraoperative hemodynamic events or adverse short-term outcomes as compared to matched cocaine-negative controls.Published by Elsevier Inc.

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