• Clin. Geriatr. Med. · May 2012

    Pharmacokinetics and pharmacodynamic changes associated with aging and implications for drug therapy.

    • Leah Church Sera and Mary Lynn McPherson.
    • Department of Pharmacy Practice and Science, University of Maryland School of Pharmacy, Baltimore, MD 21201, USA. lsera@rx.umaryland.edu
    • Clin. Geriatr. Med. 2012 May 1; 28 (2): 273-86.

    AbstractThe population of older adults continues to increase, and polypharmacy in this population is more the rule than the exception. Physiologic changes that occur with aging result in multiple alterations to the pharmacokinetics and pharmacodynamics of drugs, which, in turn, increase the risk of adverse drug reactions. Consideration of initial dose adjustment, along with frequent medication reconciliation and analysis of the medication list, are keys to providing optimal pharmaceutical care for elderly patients.

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