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Pediatric blood & cancer · Feb 2009
Levetiracetam for seizures in children with brain tumors and other cancers.
- Sonia Partap and Paul Graham Fisher.
- Department of Neurology, Stanford University, California, USA. spartap@stanford.edu)
- Pediatr Blood Cancer. 2009 Feb 1; 52 (2): 288-9.
AbstractChildren with brain tumors and other cancers can suffer from seizures. Unfortunately, most antiepileptic therapies are metabolized by the hepatic cytochrome P450 (CYP) system. Levetiracetam, a newer anticonvulsant, does not undergo CYP metabolism and does not alter the pharmacokinetics of chemotherapy, antiemetics, and corticosteroids, which are metabolized by the liver. We studied 23 patients with cancer and seizures treated with levetiracetam. Over 95% of patients had fewer seizures, with 65.2% becoming seizure free; only one patient experienced an adverse reaction. Levetiracetam is effective and well tolerated in children with brain tumors and other cancers, who are often on multiple enzyme-inducing drugs.(c) 2008 Wiley-Liss, Inc.
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