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Biomed. Pharmacother. · Jul 2017
Co-administration of creatine and guanidinoacetic acid for augmented tissue bioenergetics: A novel approach?
- Sergej M Ostojic.
- Faculty of Sport and PE, University of Novi Sad, Novi Sad, Serbia; University of Belgrade School of Medicine, Belgrade, Serbia. Electronic address: sergej.ostojic@chess.edu.rs.
- Biomed. Pharmacother. 2017 Jul 1; 91: 238-240.
AbstractA confined absorption of exogenous creatine through creatine transporter (CRT1) seems to hamper its optimal uptake in bioenergetical deficits. Co-administration of guanidinoacetic acid (GAA) along with creatine could target other transport channels besides CRT1, and supremely improve cellular levels of creatine. This innovative approach might tackle tissues difficult to reach with conventional creatine interventions, providing a potentially more effective and safe mixture in clinical pharmacology and therapeutics.Copyright © 2017 Elsevier Masson SAS. All rights reserved.
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