• Norihisa Yasuda, Koji Goto, Junya Kusaka, Akira Hasegawa, Seigo Hidaka, Takaaki Kitano, Hideo Iwasaka, and Takayuki Noguchi.
• Department of Anesthesiology, Faculty of Medicine, Oita University, Oita.
• Masui. 2005 Jul 1; 54 (7): 752-6.

BackgroundWe evaluated the effect of landiolol, a novel ultra-short-acting receptor-selective blocker, on bispectral index scale (BIS).MethodsTen patients scheduled for off-pump coronary artery bypass (OPCAB) surgery under fast-track cardiac anesthesia were analyzed. Anesthesia was maintained with appropriate additional administration of fentanyl (total dose: 10-15 microg x kg(-1)) and vecuronium under inhalation of a mixture of oxygen, air and sevoflurane (less than 2%). Landiolol was administered continuously for 5 min, when the heart rate (HR) was 80 or more per minute and the BIS values were kept between 40-60. HR, mean arterial pressure (MAP), cardiac index (CI) and BIS values were recorded at 4 time points (after induction of anesthesia, before administration of landiolol, immediately before comple- tion of administration, and 15 minutes after completion of administration).ResultsHR decreased significantly by landiolol administration, but there were no significant changes in MAP, CI and BIS.ConclusionsThis study suggests that landiolol does not affect BIS in OPCAB surgery patients under fast-track cardiac anesthesia.

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