• Aakash Katdare, Shreya Thakkar, Shivshankar Dhepale, Dignesh Khunt, and Manju Misra.
• Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research, Ahmedabad, India.
• Nutrition. 2019 Sep 1; 65: 138-157.

AbstractSince the discovery of fatty acids, a niche has been carved for their vital role as adjuvants in drug delivery and as treatment for various diseases. The literature has repeatedly described the essential role of various fatty acids in treating a wide range of diseases and disorders, from central nervous system diseases to wound healing. The use of fatty acids has expanded to many horizons and in recent decades they have gained importance as drug delivery adjuvants in addition to their auxiliary benefits in treating various diseases. Although fatty acids aid in solving both formulation-based and therapeutic challenges to our knowledge, they have never been viewed as dual agents in modern scientific literature. The aim of this review was to provide this perspective and combine the very discreet literature about fatty acids, which includes their role as therapeutic adjuvants and drug delivery agents. It gives insights on the use of fatty acids in treating the diseases of the eye, skin, central nervous system, viral diseases, and so on. The review further discusses how the structure of fatty acids plays an important role in therapeutic activity and affects formulation stability.Copyright © 2019 Elsevier Inc. All rights reserved.

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