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Pediatr. Clin. North Am. · Feb 2017
ReviewDifferentiating Familial Neuropathies from Guillain-Barré Syndrome.
- Brett J Bordini and Priya Monrad.
- Department of Pediatrics, Section of Hospital Medicine, Nelson Service for Undiagnosed and Rare Diseases, Children's Hospital of Wisconsin, Medical College of Wisconsin, Milwaukee, WI, USA. Electronic address: bbordini@mcw.edu.
- Pediatr. Clin. North Am. 2017 Feb 1; 64 (1): 231-252.
AbstractDifferentiating Guillain-Barré syndrome (GBS) from inherited neuropathies and other acquired peripheral neuropathies requires understanding the atypical presentations of GBS and its variant forms, as well as historical and physical features suggestive of inherited neuropathies. GBS is typically characterized by the acute onset of ascending flaccid paralysis, areflexia, and dysesthesia secondary to peripheral nerve fiber demyelination. The disorder usually arises following a benign gastrointestinal or respiratory illness, is monophasic, reaches a nadir with several weeks, and responds to immunomodulatory therapy. Inherited neuropathies with onset before adulthood, whose presentation may mimic Guillain-Barré syndrome, are reviewed.Copyright © 2016 Elsevier Inc. All rights reserved.
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