• Eksal Kargi, Ahmet Işikdemir, Hüsnü Tokgöz, Bülent Erol, Fulden Işikdemir, Volkan Hanci, and Cem Payasli.
• Department of Plastic and Reconstructive Surgery, Karaelmas University School of Medicine, Zonguldak, Turkey. eksalk@superonline.com
• Urology. 2010 Mar 1; 75 (3): 672-5.

ObjectivesTo compare the local anesthetic effects of tramadol hydrochloride with prilocaine for circumcision procedure.MethodsThis study included 40 patients with American Surgical Association-I scores. Patients were randomly allocated to receive either 5% tramadol (2 mg/kg) plus adrenaline (0.0125/mL) (group 1, n = 20) or 2% prilocaine plus adrenaline (0.0125/mL) (group 2, n = 20). The degree of burning sensation and pain at the injection site were documented. Sensory block was assessed 1 minute after injection and the patients were asked to grade touch and pinprick sensation. Five minutes after drug administration, incision was performed and intensity of pain, felt by the patient was evaluated on a 4-point scale (0-3). Pain at the injection site and local skin reactions were also recorded.ResultsMean ages were 9.7 and 10.3 years for groups 1 and 2, respectively. Mean duration of surgery was 19.6 minutes. In control visit, 2 of 20 (10%) in group 1 and 10 of 20 (50%) children in group 2 reported extra need for oral ibuprofen (P <.05). First analgesic medication time was 9.5 (+/- 2.1) hours in group 1 and 8.7 (+/- 3.1) hours in group 2 (P >.05). Total postoperative ibuprofen consumptions were 10 and 50 mg for groups 1 and 2, respectively (P <.05).ConclusionsA combination of tramadol 5% plus adrenaline can provide a safe and effective local anesthesia during circumcision procedure and postoperative period in children.2010 Elsevier Inc. All rights reserved.

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