• Clinics in chest medicine · Jun 2016

    Comment Review

    Goal-Directed Resuscitation in Septic Shock: A Critical Analysis.

    • Daniel J Henning and Nathan I Shapiro.
    • Division of Emergency Medicine, Harborview Medical Center, University of Washington School of Medicine, 325 9th Avenue, Box 359702, Seattle, WA 98104, USA. Electronic address: henning2@uw.edu.
    • Clin. Chest Med. 2016 Jun 1; 37 (2): 231-9.

    AbstractThe Early Goal-Directed Therapy versus Standard Care for Sepsis trial by Rivers and colleagues in 2001 suggested that a significant mortality reduction may be realized through goal-directed interventions early in the care of patients with septic shock. However, the recent publication of the Protocol-Based Care for Early Septic Shock (ProCESS), Australasian Resuscitation in Sepsis Evaluation (ARISE), and Protocolised Management in Sepsis (ProMISE) trials did not demonstrate the superiority of early goal-directed therapy over usual care. If usual care includes timely and meticulous care, a protocol may not be needed to realize the continued lowering mortality rates.Copyright © 2016 Elsevier Inc. All rights reserved.

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