• Journal of neurosurgery · Jul 2003

    Topical mitomycin C-induced inhibition of postlaminectomy peridural fibrosis in rabbits.

    • Fikret Dogulu, Gokhan Kurt, Hakan Emmez, Ozlem Erdem, Leyla Memis, Kemali Baykaner, and Necdet Ceviker.
    • Department of Neurosurgery, Gazi University School of Medicine, Ankara, Turkey. fdogulu@hotmail.com
    • J. Neurosurg. 2003 Jul 1; 99 (1 Suppl): 76-9.

    ObjectThe authors conducted a study to determine the effectiveness of mitomycin C in preventing postlaminectomy peridural fibrosis in rabbits.MethodsLaminectomies were performed at L-4 in 12 rabbits. Color-coded cotton pads soaked either with 0.02% mitomycin C or saline were applied in a blinded fashion to the operative sites, with saline-treated laminectomy sites serving as controls. The rabbits were killed 30 days after surgery. The extent of peridural fibrosis was evaluated by histological analysis. The mitomycin C-treated sites showed significantly decreased peridural fibrosis.ConclusionsPeridural fibrosis can be a devastating condition that develops after laminectomy. Topical application of mitomycin C may be a successful method of preventing postlaminectomy peridural fibrosis.

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