Seronegative conversion after incomplete benznidazole

Trans. R. Soc. Trop. Med. Hyg. · Oct 2012

Seronegative conversion after incomplete benznidazole treatment in chronic Chagas disease.

In 12-18% of adult patients, treatment with benznidazole for chronic Chagas disease has to be discontinued because of side-effects. We identified and analysed a cohort of 81 adult patients with three positive tests for Trypanosoma cruzi infection and serological monitoring following incomplete treatment with benznidazole for a median of 10 days. Twenty percent of these patients (16/81) met the criteria of cure, showing that the optimal schedule of benznidazole administration remains to be determined.

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- M G Alvarez, C Vigliano, B Lococo, M Petti, G Bertocchi, and R Viotti.
- Sección Chagas, Servicio de Cardiología, Hospital Eva Perón, San Martín, Buenos Aires, Argentina.
- Trans. R. Soc. Trop. Med. Hyg. 2012 Oct 1; 106 (10): 636-8.
AbstractIn 12-18% of adult patients, treatment with benznidazole for chronic Chagas disease has to be discontinued because of side-effects. We identified and analysed a cohort of 81 adult patients with three positive tests for Trypanosoma cruzi infection and serological monitoring following incomplete treatment with benznidazole for a median of 10 days. Twenty percent of these patients (16/81) met the criteria of cure, showing that the optimal schedule of benznidazole administration remains to be determined.Copyright © 2012 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.

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Seronegative conversion after incomplete benznidazole treatment in chronic Chagas disease.

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