• World Neurosurg · Feb 2020

    An Integrative Survival Analysis for Multicentric Low-grade Glioma.

    • Tianwei Wang, Yanping Yang, Xiaoke Xu, Xiaodong Niu, Renhao Yang, Ting Gao, Lin Kong, Qing Mao, and Yongming Qiu.
    • Department of Neurosurgery, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
    • World Neurosurg. 2020 Feb 1; 134: e189-e195.

    ObjectiveThis study aimed to perform a survival analysis of patients with multicentric low-grade gliomas (MLGGs) and to assess the influence of various prognostic factors on progression-free survival (PFS) and overall survival.MethodsA literature search on Web of Science and PubMed was performed for literature in English published from 1963 to September 2018. Detailed information including demographics, clinical characteristics, treatments, critical events, and time to events for survival analysis were extracted from the included articles.ResultsA total of 36 cases from published articles were selected for analysis. Univariate analysis showed that age (<31 years or ≥31 years), grade (pure low grade/low and high grade) and glioma type (astrocytoma/oligodendroglioma) had a significant relationship with PFS. Cox regression analysis showed that tumor grade was an independent prognostic factor for PFS. No factors correlated with overall survival.ConclusionsThis integrative analysis of MLGGs patients revealed that age younger than 31 years, pure MLGG, and oligodendroglioma were significantly associated with improved PFS, and pure MLGGs was an independent prognostic factors for PFS.Copyright © 2019 Elsevier Inc. All rights reserved.

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