• E Di Leo, P Delle Donne, G F Calogiuri, L Macchia, and E Nettis.
• Unit of Internal Medicine, Section of Allergy and Clinical Immunology, "F. Miulli" Hospital, Acquaviva delle Fonti, BA Italy.
• Clin Mol Allergy. 2018 Jan 1; 16: 16.

AbstractAdverse reactions (ARs) to drugs administered during general anesthesia may be very severe and life-threatening, with a mortality rate ranging from 3 to 9%. The adverse reactions to drugs may be IgE and non-IgE-mediated. Neuromuscular blocking agents (NMBA) represent the first cause of perioperative reactions during general anesthesia followed by latex, antibiotics, hypnotic agents, opioids, colloids, dyes and antiseptics (chlorhexidine). All these substances (i.e. NMBA, anesthetics, antibiotics, latex devices) may cause severe systemic non-IgE-mediated reactions or fatal anaphylactic events even in the absence of any evident risk factor in the patient's anamnesis. For this reason, in order to minimize perioperative anaphylactic reactions, it is important to have rapid, specific, sensitive in vitro diagnostic tests able to confirm the clinical diagnosis of acute anaphylaxis.

This article appears in the collection: Anaphylaxis to Rocuronium in Australia & New Zealand.

4 keywords...

hide…