• Curr Pain Headache Rep · Apr 2002

    Review

    AIDS and AIDS-treatment neuropathies.

    • Derek Williams, Anthony Geraci, and David M Simpson.
    • Mount Kisco Medical Group, 90 South Bedford Road, Mount Kisco, NY 10549, USA. AGeraci@mkmg.com
    • Curr Pain Headache Rep. 2002 Apr 1; 6 (2): 125-30.

    AbstractAIDS and AIDS-treatment neuropathies are common in individuals infected with HIV. As patients live longer due to improved antiretroviral therapies, the impact of painful neuropathy on patients' lives may increase. Several antiretroviral medications are known to cause toxic neuropathy in patients with AIDS, but this may be outweighed by the beneficial effects of viral suppression. Current theories on the pathogenesis of AIDS neuropathies include mitochondrial toxicity secondary to gamma-DNA polymerase inhibition and subsequent abnormal mitochondrial DNA synthesis. Treatment of AIDS neuropathies is directed toward relief of symptoms; however, new evidence suggests that aggressive antiretroviral therapy may also be effective.

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