• Zhongguo Zhong Yao Za Zhi · Feb 2014

    [Preparation and in vitro study on diffusion of capsaicin cubosome].

    • Xin-Sheng Peng, Yan-Fang Zhou, Ke Han, Ling-Zhen Qin, and Chuan-Bin Wu.
    • Zhongguo Zhong Yao Za Zhi. 2014 Feb 1; 39 (4): 644-7.

    AbstractThis study was to investigate the permeability and absorbability of capsaicin cubosome across abdominal skin of the SD rats in vitro. Diffusion of capsaicin cubosome and cream was performed with the modified Franz diffusion cell technique. The capsaicin cubosome showed no enhancement of skin permeation within 24 hours. However, the deposition amounts of capsaicin in the rat skin in the cubosome group was markedly higher than those in the commercial cream group (P < 0.01). Cubosome showed excellent characetristic of skin-targed which could be a good carrier for the local transdermal drug delivery system.

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