• Fertility and sterility · Dec 2016

    Fertility treatment and childhood type 1 diabetes mellitus: a nationwide cohort study of 565,116 live births.

    • Laura Ozer Kettner, Niels Bjerregaard Matthiesen, Cecilia Høst Ramlau-Hansen, Ulrik Schiøler Kesmodel, Bjørn Bay, and Tine Brink Henriksen.
    • Perinatal Epidemiology Research Unit and Department of Pediatrics, Aarhus University Hospital, Aarhus, Denmark. Electronic address: laura@kettner.nu.
    • Fertil. Steril. 2016 Dec 1; 106 (7): 1751-1756.

    ObjectiveTo investigate the association between specific types of fertility treatment and childhood type 1 diabetes mellitus.DesignNationwide birth cohort study.SettingNot applicable.Patient(S)All pregnancies resulting in a live-born singleton child in Denmark from 1995 to 2003.Intervention(S)Not applicable.Main Outcome Measure(S)Childhood type 1 diabetes mellitus identified from redeemed prescriptions for insulin until 2013.Result(S)The study included 565,116 singleton pregnancies. A total of 14,985 children were conceived by ovulation induction or intrauterine insemination, and 8,490 children were conceived by in vitro fertilization or intracytoplasmic sperm injection. During the follow-up period, 2,011 (0.4%) children developed type 1 diabetes mellitus. The primary analyses showed no association between fertility treatment and childhood type 1 diabetes mellitus. In secondary analyses, ovulation induction or intrauterine insemination with follicle-stimulating hormone was associated with an increased risk of type 1 diabetes mellitus (hazard ratio 3.22; 95% confidence interval 1.20 to 8.64). No clear associations were seen with other types of fertility treatment or with specific treatment indications.Conclusion(S)No association between fertility treatment and childhood type 1 diabetes mellitus was found. Ovulation induction or intrauterine insemination with follicle-stimulating hormone may be associated with an increased risk of childhood type 1 diabetes mellitus. However, this finding may be due to chance or to confounding by indication and thus requires further investigation.Copyright © 2016 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

      Pubmed     Full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…