• Joshua Osowicki, Sarah Kapur, Linny Kimly Phuong, and Simon Dobson.
• Group A Streptococcal Research Group, Murdoch Childrens Research Institute, Melbourne, Victoria, Australia; Division of Infectious Diseases, Department of Pediatrics, University of British Columbia, BC Children's Hospital, Vancouver, British Columbia, Canada; Department of Paediatrics, University of Melbourne, Melbourne, Victoria, Australia; Infectious Diseases unit, The Royal Children's Hospital Melbourne, Victoria, Australia; Department of Paediatric Infection and Immunity, Monash Children's Hospital, Clayton, Australia. Electronic address: joshua.osowicki@rch.org.au.
• J. Infect. 2017 Jun 1; 74 Suppl 1: S47-S53.

AbstractLemierre's syndrome is a rare and feared complication of pharyngitis, occurring most commonly in adolescents and young adults. It is typically defined by the constellation of septic internal jugular vein thrombophlebitis, pulmonary and other septic emboli, and sterilesite infection by Fusobacterium necrophorum. The rarity and severity of Lemierre's syndrome has made it an attractive subject for case reports but there is a paucity of evidence to inform areas of persistent uncertainty. In recent years, heightened attention and controversy has focused upon speculation that a purported rise in the incidence of Lemierre's syndrome is due to reduced antibiotic prescribing for respiratory tract infections, that F. necrophorum is an under-appreciated cause of acute tonsillopharyngitis and that testing and targeted treatment would prevent cases of Lemierre's syndrome.© 2017 The British Infection Association. Published by Elsevier Ltd. All rights reserved.

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