• Ann Dermatol Vener · Aug 1998

    Case Reports

    [Aggravation of acne by isotretinoin. 6 cases, predictive factors].

    • D Lehucher Ceyrac, C Chaspoux, L Sulimovic, P Morel, and H Lefrancq.
    • Service Dermatologie, Hôpital Saint-Louis, Paris.
    • Ann Dermatol Vener. 1998 Aug 1; 125 (8): 496-9.

    ObjectiveAcne flare-ups are frequent in the early phase of isotretinoin treatment. Severity varies from one patient to another. Clinical factors favoring a potentially severe course were assessed on the basis of 6 cases.Case ReportsSix male patients, mean age 16.5 years, with inflammatory acne with a major retentional component were studied. Isotretinoin administered at a daily dose 0.5 mg/kg led to explosive development of massive nodulocystic lesions or pyogenic granulomas within two months. The lesions healed at withdrawal of isotretinoin and administration of antibiotics and antiinflammatory drugs. There was important scar sequellae.DiscussionFour concomitant factors were identified which contribute to the development of acne flare-ups: sex (male), young age, retentional form of acne and daily isotretinoin dose 0.5 mg/kg.

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