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Infect. Dis. Clin. North Am. · Dec 2017
ReviewAntimicrobial Pharmacokinetics and Pharmacodynamics in Older Adults.
- John M Benson.
- Promise Hospital of Salt Lake, 8th Avenue and C Street, Salt Lake City, UT 84143, USA; College of Pharmacy, University of Utah, 30 South 2000 East, Salt Lake City, UT 84112, USA. Electronic address: john.benson@promisehealthcare.com.
- Infect. Dis. Clin. North Am. 2017 Dec 1; 31 (4): 609-617.
AbstractAntimicrobial use in older adults requires working knowledge of the pharmacokinetics and pharmacodynamics of these drugs, and the alterations known to occur with these models as patients age. A summary of pharmacokinetic principles relevant to antimicrobials and an overview of published medical literature describing pharmacokinetic changes known to correlate with age are presented. Pharmacodynamic models that apply to antibacterial agents are reviewed, as are likely effects of aging on these models. The understanding of how older adults respond in terms of efficacy and toxicity is increasing but limited. Further research into the effects of aging on the actions of antimicrobials in the elderly is needed.Copyright © 2017 Elsevier Inc. All rights reserved.
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