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Critical care clinics · Apr 2009
ReviewPotential uses of hemoglobin-based oxygen carriers in critical care medicine.
- Jacques Creteur and Jean-Louis Vincent.
- Department of Intensive Care, Erasme Hospital, Université libre de Bruxelles, Brussels, Belgium.
- Crit Care Clin. 2009 Apr 1; 25 (2): 311-24, Table of Contents.
AbstractHemoglobin-based oxygen carriers (HBOCs) were initially developed to provide an alternative to blood transfusion. With the realization that hemoglobin solutions not only are red blood cell substitutes but also have a number of additional properties, including hemodynamic effects related to their oncotic and nitric oxide-scavenging effects, the broader concept of "hemoglobin therapeutics" was born. Promising effects on oxygen transport and the microcirculation need to be confirmed, and the results of studies with newer, second-generation HBOCs are eagerly awaited. In the meantime, possible adverse effects need to be carefully evaluated before HBOCs can be widely used in the ICU, emergency room, or prehospital setting.
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