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- M Thibonnier, L N Berti-Mattera, N Dulin, D M Conarty, and R Mattera.
- Department of Medicine, Case Western Reserve University, School of Medicine, Cleveland, OH 44106-4951, USA. mxt10@po.cwru.edu
- Prog. Brain Res. 1998 Jan 1; 119: 147-61.
AbstractVasopressin (VP) and oxytocin (OT) are cyclic nonapeptides whose actions are mediated by stimulation of specific G protein-coupled receptors (GPCRs) currently classified into V1-vascular (V1R), V2-renal (V2R) and V3-pituitary (V3R) VP receptors and OT receptors (OTR). The recent cloning of the different members of the VP/OT family of receptors now allows the extensive characterization of the molecular determinants involved in ligand binding and signal transduction pathways coupled to a given VP/OT receptor subtype in stably transfected mammalian cell lines. In this article, we review the present knowledge of the signal transduction pathways coupled to the different VP/OT receptor subtypes and we present new observations derived from the study of each human VP or OT receptor subtype stably expressed in CHO cells.
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