• Mark D Neuman, Sean Hennessy, Dylan S Small, Craig Newcomb, Lakisha Gaskins, Colleen M Brensinger, Duminda N Wijeysundera, Brian T Bateman, and Hannah Wunsch.
• From the Department of Anesthesiology and Critical Care (M.D.N., L.G.) Center for Perioperative Outcomes Research and Transformation (M.D.N., L.G.) Center for Pharmacoepidemiology Research and Training (M.D.N., S.H., D.S.S.) Department of Biostatistics, Epidemiology, and Informatics (S.H.) Center for Clinical Epidemiology and Biostatistics (S.H., D.S.S.,C.N., C.M.B.), Perelman School of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, Pennsylvania (M.D.N., S.H., D.S.S.) Department of Statistics, The Wharton School, University of Pennsylvania, Philadelphia, Pennsylvania (D.S.S.) Department of Anesthesia, St. Michael's Hospital and University of Toronto, Toronto, Ontario, Canada (D.N.W.) Department of Anesthesia, Perioperative, and Pain Medicine and Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts (B.T.B.) Department of Critical Care Medicine, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada (H.W.) Department of Anesthesia and Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Ontario, Canada (H.W.).
• Anesthesiology. 2020 May 1; 132 (5): 1151-1164.

BackgroundIn 2014, the U.S. Drug Enforcement Agency reclassified hydrocodone from Schedule III to Schedule II of the Controlled Substances Act, resulting in new restrictions on refills. The authors hypothesized that hydrocodone rescheduling led to decreases in total opioid dispensing within 30 days of surgery and reduced new long-term opioid dispensing among surgical patients.MethodsThe authors studied privately insured, opioid-naïve adults undergoing 10 general or orthopedic surgeries between 2011 and 2015. The authors conducted a differences-in-differences analysis that compared overall opioid dispensing before versus after the rescheduling rule for patients treated by surgeons who frequently prescribed hydrocodone before rescheduling (i.e., patients who were functionally exposed to rescheduling's impact) while adjusting for secular trends via a comparison group of patients treated by surgeons who rarely prescribed hydrocodone (i.e., unexposed patients). The primary outcome was any filled opioid prescription between 90 and 180 days after surgery; secondary outcomes included the 30-day refill rate and the amount of opioids dispensed initially and at 30 days postoperatively.ResultsThe sample included 65,136 patients. The percentage of patients filling a prescription beyond 90 days was similar after versus before rescheduling (absolute risk difference, -1.1%; 95% CI, -2.3% to 0.1%; P = 0.084). The authors estimated the rescheduling rule to be associated with a 45.4-mg oral morphine equivalent increase (difference-in-differences estimate; 95% CI, 34.2-56.7 mg; P < 0.001) in initial opioid dispensing, a 4.1% absolute decrease (95% CI, -5.5% to -2.7%; P < 0.001) in refills within 30 days, and a 37.7-mg oral morphine equivalent increase (95% CI, 20.6-54.8 mg; P = 0.008) in opioids dispensed within 30 days.ConclusionsAmong patients treated by surgeons who frequently prescribed hydrocodone before the Drug Enforcement Agency 2014 hydrocodone rescheduling rule, rescheduling did not impact long-term opioid receipt, although it was associated with an increase in opioid dispensing within 30 days of surgery.

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