• Hakan Tekgüç, CanFulya KamitFKTepecik Hospital, Pediatric ICU, Pediatrics, Izmir, Turkey., Güntülü Şik, Demet Demirkol, Deniz Özel, Ayhan Yaman, Rana Işgüder, Dinçer Yildiztaş, Nazik A Yener, Nilufer Y Öztürk, Utku Karaarslan, Seher Erdoğan, Pinar Yazci, Ener C Dinleyici, Tahir Dalkiran, Esra Şevketoğlu, Ayse Berna Anil, Agop Çitak, Fatih Aygün, Tanil Kendirli, Hasan Ağin, Ozden O Horoz, Şükrü Paksu, Feyza G İnceköy, Mehmet Davutoğlu, Tolga Köroğlu, Mehmet Boşnak, Bülent Karapinar, and Oğuz Dursun.
• Burhan Nalbantoglu Hastanesi, Lefkosa, KKTC, Mersin, Turkey.
• Pediatr Crit Care Me. 2020 May 1; 21 (5): e253-e258.

ObjectivesTo investigate conventional mechanical ventilation weaning characteristics of patients requiring conventional mechanical ventilation support for greater than 48 hours within the PICU.DesignThe prospective observational multicenter cohort study was conducted at 15 hospitals. Data were being collected from November 2013 to June 2014, with two designated researchers from each center responsible for follow-up and data entry.SettingFifteen tertiary PICUs in Turkey.PatientsPatients between 1 month and 18 years old requiring conventional mechanical ventilation for greater than 48 hours were included. A single-center was not permitted to surpass 20% of the total sample size. Patients with no plans for conventional mechanical ventilation weaning were excluded.InterventionsConventional mechanical ventilation MEASUREMENTS AND MAIN RESULTS:: Pertinent variables included PICU and patient demographics, including clinical data, chronic diseases, comorbid conditions, and reasons for intubation. Conventional mechanical ventilation mode and weaning data were characterized by daily ventilator parameters and blood gases. Patients were monitored until hospital discharge. Of the 410 recruited patients, 320 were included for analyses. A diagnosis of sepsis requiring intubation and high initial peak inspiratory pressures correlated with a longer weaning period (mean, 3.65 vs 1.05-2.17 d; p < 0.001). Conversely, age, admission Pediatric Risk of Mortality III scores, days of conventional mechanical ventilation before weaning, ventilator mode, and chronic disease were not related to weaning duration.ConclusionsPediatric patients requiring conventional mechanical ventilation with a diagnosis of sepsis and high initial peak inspiratory pressures may require longer conventional mechanical ventilation weaning prior to extubation. Causative factors and optimal weaning for this cohort needs further consideration.

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