• Critical care clinics · Apr 2020

    Review

    Endothelial Glycocalyx.

    • Jan Jedlicka, Bernhard F Becker, and Daniel Chappell.
    • Department of Anaesthesiology, University Hospital of Munich (LMU), Nussbaumstr. 20, Munich 80336, Germany.
    • Crit Care Clin. 2020 Apr 1; 36 (2): 217-232.

    AbstractThe endothelial glycocalyx (EG) is the most luminal layer of the blood vessel, growing on and within the vascular wall. Shedding of the EG plays a central role in many critical illnesses. Degradation of the EG is associated with increased morbidity and mortality. Certain illnesses and iatrogenic interventions can cause degradation of the EG. It is not known whether restitution of the EG promotes the survival of the patient. First trials that focus on the reorganization and/or restitution of the EG seem promising. Nevertheless, the step "from bench to bedside" is still a big one.Copyright © 2020 Elsevier Inc. All rights reserved.

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