• Critical care clinics · Apr 2020

    Review

    Microvascular Dysfunction in the Critically Ill.

    • Can Ince, Daniel De Backer, and Philip R Mayeux.
    • Department of Intensive Care, Laboratory of Translational Intensive Care, Erasmus MC, University Medical Center, Dr Molewaterplein 40, 3015 GD Rotterdam, the Netherlands.
    • Crit Care Clin. 2020 Apr 1; 36 (2): 323-331.

    AbstractMicrovascular dysfunction is a frequent complication of many chronic and acute conditions, especially in the critically ill. Moreover, the severity of microvascular alterations is associated with development of organ dysfunction and poor outcome. The complexities and heterogeneity of critical illness, especially in the elderly patient, requires more mechanistically oriented clinical trials that monitor the effectiveness of existing therapies and of those to come. Recent advances in the ability to obtain physiologically based assessments of microcirculatory function at the bedside will make microcirculatory-guided resuscitation a point of care reality.Copyright © 2019 Elsevier Inc. All rights reserved.

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