• Jeffrey S Pollak.
• Department of Radiology and Biomedical Imaging, Section of Vascular and Interventional Radiology, Yale University School of Medicine, PO Box 208042, 333 Cedar Street, New Haven, CT 06520-8042, USA. Electronic address: jeffrey.pollak@yale.edu.
• Clin. Chest Med. 2018 Sep 1; 39 (3): 651-658.

AbstractMore aggressive therapy for acute pulmonary embolism beyond anticoagulation is indicated in patients at higher risk for mortality and morbidity, namely those suffering from massive and possibly submassive disease. Catheter-based thrombolysis, catheter-based mechanical thrombus debulking, or combinations of these offer opportunities for rapid clot reduction and clinical improvement with a lower bleeding risk than systemic thrombolysis and perhaps greater efficacy. Optimal low-dose regimens for direct thrombolysis have not been defined just as optimal techniques and devices for mechanical therapy have not been developed, underscoring the need for further work.Copyright © 2018 Elsevier Inc. All rights reserved.

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