• Gary E Weissman, Andrew Crane-Droesch, Corey Chivers, ThaiBinh Luong, Asaf Hanish, Michael Z Levy, Jason Lubken, Michael Becker, Michael E Draugelis, George L Anesi, Patrick J Brennan, Jason D Christie, C William Hanson, Mark E Mikkelsen, and Scott D Halpern.
• University of Pennsylvania, Philadelphia, Pennsylvania (G.E.W., M.Z.L., G.L.A., P.J.B., J.D.C., C.W.H., M.E.M., S.D.H.).
• Ann. Intern. Med. 2020 Jul 7; 173 (1): 21-28.

BackgroundThe coronavirus disease 2019 (COVID-19) pandemic challenges hospital leaders to make time-sensitive, critical decisions about clinical operations and resource allocations.ObjectiveTo estimate the timing of surges in clinical demand and the best- and worst-case scenarios of local COVID-19-induced strain on hospital capacity, and thus inform clinical operations and staffing demands and identify when hospital capacity would be saturated.DesignMonte Carlo simulation instantiation of a susceptible, infected, removed (SIR) model with a 1-day cycle.Setting3 hospitals in an academic health system.PatientsAll people living in the greater Philadelphia region.MeasurementsThe COVID-19 Hospital Impact Model (CHIME) (http://penn-chime.phl.io) SIR model was used to estimate the time from 23 March 2020 until hospital capacity would probably be exceeded, and the intensity of the surge, including for intensive care unit (ICU) beds and ventilators.ResultsUsing patients with COVID-19 alone, CHIME estimated that it would be 31 to 53 days before demand exceeds existing hospital capacity. In best- and worst-case scenarios of surges in the number of patients with COVID-19, the needed total capacity for hospital beds would reach 3131 to 12 650 across the 3 hospitals, including 338 to 1608 ICU beds and 118 to 599 ventilators.LimitationsModel parameters were taken directly or derived from published data across heterogeneous populations and practice environments and from the health system's historical data. CHIME does not incorporate more transition states to model infection severity, social networks to model transmission dynamics, or geographic information to account for spatial patterns of human interaction.ConclusionPublicly available and designed for hospital operations leaders, this modeling tool can inform preparations for capacity strain during the early days of a pandemic.Primary Funding SourceUniversity of Pennsylvania Health System and the Palliative and Advanced Illness Research Center.

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