• British medical bulletin · Sep 2019

    New concepts in C. difficile management.

    • Y R Mahida.
    • Nottingham Digestive Diseases Centre, Queen's Medical Centre, Nottingham, UK.
    • Br. Med. Bull. 2019 Sep 19; 131 (1): 109-118.

    BackgroundClostridium difficile infection is transmitted via spores, and the disease is mediated via secreted toxins. It represents a significant healthcare problem, and clinical presentation can range from asymptomatic carriage to life-threatening pseudomembranous colitis.Sources Of Datapublications in the field, with a focus on recent developments and concepts.Areas Of Agreementinfection control measures, antibiotic stewardship and current management of the initial episode of C. difficile infection.Areas Of Controversyselection and sequence of interventions for the management of recurrent C. difficile infection; management of persistent carriers of toxigenic C. difficile in patients at high risk of subsequent C. difficile infection.Growing Pointsuse of faecal microbiota transplantation for recurrent C. difficile infection.Areas Timely For Developing Researchrole of specific microbiota-mediated interventions and vaccination in the treatment and prevention of C. difficile infection.© The Author(s) 2019. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

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