• Thomas Pekar, Aribert Wendzel, Walter Flak, Alexandra Kremer, Susanne Pauschenwein-Frantsich, Anna Gschaider, Felix Wantke, and Reinhart Jarisch.
• Biomedical Science, University of Applied Sciences Wiener Neustadt, Johannes-Gutenberg-Straße 3, 2700, Wiener Neustadt, Austria. pekar@fhwn.ac.at.
• Wien. Klin. Wochenschr. 2020 Jan 1; 132 (1-2): 424642-46.

AbstractPrevious studies have highlighted that spermidine has the ability to trigger the important process of dissolving amyloid-beta plaques by autophagy. This manuscript focuses on the correlation of serum spermidine levels between age and between performance in mini-mental state examinations. It will serve as a premise for an ongoing multicentric placebo-controlled study, which focuses on the effect of oral spermidine supplementation on memory performance. Memory tests were carried out on 80 subjects aged 60-96 years old in 6 nursing homes in Styria. Blood samples were taken for the determination of spermidine concentration. The results showed a significant correlation between the spermidine concentration and the mini-mental state examination score (p = 0.025). On the basis of the dependence demonstrated it can be concluded that spermidine might be suitable as a biomarker for the diagnosis of neurocognitive changes (senile dementia or Alzheimer's disease).

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