• Aurelio Perez-Favila, Margarita L Martinez-Fierro, Jessica G Rodriguez-Lazalde, Miguel A Cid-Baez, Michelle de J Zamudio-Osuna, Ma Del Rosario Martinez-Blanco, Fabiana E Mollinedo-Montaño, Iram P Rodriguez-Sanchez, Rodrigo Castañeda-Miranda, and Idalia Garza-Veloz.
• Molecular Medicine Laboratory, Unidad Academica de Medicina Humana y Ciencias de la Salud, Universidad Autonoma de Zacatecas, Carretera Zacatecas-Guadalajara Km.6. Ejido la Escondida, C.P., Zacatecas 98160, Mexico.
• Medicina (Kaunas). 2019 Oct 25; 55 (11).

AbstractDiabetic foot ulcers (DFUs) are the fastest growing chronic complication of diabetes mellitus, with more than 400 million people diagnosed globally, and the condition is responsible for lower extremity amputation in 85% of people affected, leading to high-cost hospital care and increased mortality risk. Neuropathy and peripheral arterial disease trigger deformities or trauma, and aggravating factors such as infection and edema are the etiological factors for the development of DFUs. DFUs require identifying the etiology and assessing the co-morbidities to provide the correct therapeutic approach, essential to reducing lower-extremity amputation risk. This review focuses on the current treatment strategies for DFUs with a special emphasis on tissue engineering techniques and regenerative medicine that collectively target all components of chronic wound pathology.

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