• Julie L Priest, Tanya Burton, Cori Blauer-Peterson, Kate Andrade, and Alan Oglesby.
• ViiV Healthcare, 5 Moore Dr, Durham, NC 27709. Email: julie.l.priest@viivhealthcare.com.
• Am J Manag Care. 2019 Dec 1; 25 (12): 580-586.

ObjectivesDescribe the clinical characteristics and treatment patterns of patients with HIV-1 who have commercial or Medicare health insurance in the United States.Study DesignRetrospective cohort study.MethodsAdministrative claims for adult commercial and Medicare health plan enrollees with evidence of HIV-1 and antiretroviral therapy (ART) between January 1, 2007, and March 31, 2017, were assessed. Current and previous complete ART regimens were identified using a claims-based algorithm. Results were stratified by treatment status and insurance type.ResultsOf 18,699 eligible patients, 5027 (27%) had no previous ART regimens; 15,275 (82%) had commercial insurance. Mean age was 47.5 years. Common comorbidities included hyperlipidemia, cardiovascular disease, hypertension, depression, and anxiety. The mean number of ART regimens was 1.43, with 31% of patients having 2 or more regimens. Mean (SD) daily pill burden was higher in patients with more than 1 ART regimen over time (5.7 [6.0] pills) or with Medicare insurance (9.2 [8.0] pills) than in patients with no previous ART (1.9 [4.4] pills) or with commercial insurance (3.7 [4.7] pills). Overall, 60% of patients achieved 90% or greater adherence to their ART regimen and 16% had a prescription filled for any contraindicated medication to an ART during their regimen.ConclusionsThis descriptive study demonstrated that people living with HIV enrolled in Medicare have a significant amount of comorbidities and total pill burden. Although advancements in ART have significantly improved life expectancy and quality of life for people living with HIV, it is important to take into account individual complexities such as comorbidities and pill burden when selecting ART regimens.

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